Pleural Mesothelioma Life Expectancy


Pleural mesothelioma is a rare and aggressive form of cancer that affects the lining of the lungs, known as the pleura. This type of cancer primarily results from exposure to asbestos, a once widely-used material in various industries due to its heat resistance and durability. The latency period between asbestos exposure and the development of pleural mesothelioma can be quite long, often spanning several decades. Consequently, the disease is frequently diagnosed in its later stages, which can result in a reduced life expectancy for affected individuals.

Understanding the factors that influence life expectancy and the treatment options available is crucial for patients and their families as they navigate the challenges associated with pleural mesothelioma. This article aims to provide comprehensive information on the disease, its causes, and symptoms, as well as the factors that can impact life expectancy. Moreover, we will explore the various treatments that have the potential to improve survival rates and enhance patients’ quality of life. By empowering patients and their loved ones with knowledge and resources, we hope to offer support and guidance during this difficult journey.

What is Pleural Mesothelioma?

Pleural mesothelioma is a type of cancer that originates in the mesothelial cells found in the pleura. The pleura is a thin membrane that lines the lungs and chest cavity, providing protection and lubrication during respiration.

Causes of Pleural Mesothelioma

The primary cause of pleural mesothelioma is exposure to asbestos, a naturally occurring mineral that has been widely used in various industries due to its heat resistance and durability. Asbestos fibers can become airborne and, when inhaled, can become lodged in the pleura, leading to inflammation, scarring, and eventually, cancer.

Symptoms of Pleural Mesothelioma

Common symptoms of pleural mesothelioma include:

  • Chest pain
  • Shortness of breath
  • Fatigue
  • Weight loss
  • Persistent cough

Factors Affecting Life Expectancy in Pleural Mesothelioma

There are several factors that can influence life expectancy for individuals with pleural mesothelioma:

Stage of the Disease

The stage at which pleural mesothelioma is diagnosed plays a significant role in determining life expectancy. Early-stage diagnoses often have better prognosis, as treatment options are more effective and the cancer is less likely to have spread.

Age and Overall Health

Younger patients and those in better overall health generally have a better life expectancy, as they are better equipped to handle the side effects of treatment and have stronger immune systems.

Treatment Options

The choice of treatment can also have a significant impact on life expectancy. Certain treatments are more effective for some patients, while others may not be suitable due to factors such as age, overall health, and the stage of the disease.

Improving Life Expectancy with Treatment

There are several treatment options available for pleural mesothelioma, each with its own potential to improve life expectancy:


Surgical procedures can help remove the tumor and surrounding tissue, which may increase life expectancy. There are several surgical options, including pleurectomy/decortication (P/D) and extrapleural pneumonectomy (EPP). The choice of surgery depends on the patient’s overall health, the stage of the disease, and the extent of the tumor.


Chemotherapy is often used in combination with surgery to kill remaining cancer cells and prevent recurrence. Commonly used chemotherapy drugs for pleural mesothelioma include cisplatin and pemetrexed. Chemotherapy may help extend life expectancy, especially when used as part of a multimodal treatment plan.

Radiation Therapy

Radiation therapy uses high-energy beams to target and kill cancer cells. This treatment can be administered externally or internally (brachytherapy). While radiation therapy may not significantly extend life expectancy, it can help alleviate symptoms and improve the quality of life for patients.


Immunotherapy is a relatively new treatment option that uses the body’s immune system to fight cancer cells. Certain immunotherapy drugs, such as pembrolizumab and nivolumab, have shown promise in extending life expectancy for some pleural mesothelioma patients.

Multimodal Therapy

Multimodal therapy involves a combination of two or more treatment options, such as surgery, chemotherapy, and radiation therapy. This approach has been shown to improve life expectancy for some pleural mesothelioma patients, particularly when treatments are tailored to the individual’s specific needs and circumstances.

Coping with Pleural Mesothelioma

Emotional and Mental Health

Dealing with a pleural mesothelioma diagnosis can be challenging, both emotionally and mentally. It’s essential for patients and their families to seek emotional support and maintain open communication. Professional counseling and therapy can also help in coping with the diagnosis and managing stress.

Palliative Care

Palliative care focuses on providing relief from symptoms and improving the quality of life for patients with serious illnesses, such as pleural mesothelioma. This type of care can be an essential part of the overall treatment plan, ensuring that patients remain comfortable and maintain a good quality of life throughout the treatment process.

Support Groups and Resources

Joining a support group or connecting with other patients and families dealing with pleural mesothelioma can provide valuable emotional support and practical advice. There are several online resources and organizations dedicated to providing information, support, and advocacy for mesothelioma patients and their families.


Pleural mesothelioma is an aggressive and challenging disease that often presents patients and their families with an uncertain future. However, with ongoing advancements in medical research and the development of new treatment options, there is hope for improved outcomes and an increased life expectancy for some patients. A proactive approach to managing the disease, including seeking timely diagnosis, exploring various treatment options, and engaging with specialists, can make a significant difference in the overall prognosis.

Furthermore, maintaining a strong support system is essential for both the patient and their family. This support can come in many forms, including emotional support from friends and loved ones, professional counseling, and participation in support groups. By connecting with others who are going through similar experiences, patients can gain valuable insights and practical advice, which can help them navigate the complexities of pleural mesothelioma.

In addition to medical treatments, focusing on a patient’s quality of life is of utmost importance. Palliative care plays a crucial role in managing symptoms, alleviating discomfort, and ensuring that patients maintain a good quality of life throughout their treatment journey. By embracing a holistic approach to treatment, patients can enhance their overall well-being and potentially improve their life expectancy.

In conclusion, while pleural mesothelioma remains a formidable challenge, a combination of medical advancements, personalized treatment plans, and comprehensive support can offer hope for better outcomes and an improved quality of life for those affected by this rare and aggressive cancer.


  1. What is the average life expectancy for someone with pleural mesothelioma?The average life expectancy for pleural mesothelioma patients ranges from 12 to 21 months. However, this can vary significantly depending on factors such as the stage of the disease, age, overall health, and the chosen treatment options.
  2. Can pleural mesothelioma be cured?While there is currently no cure for pleural mesothelioma, treatments can help manage the disease, alleviate symptoms, and potentially extend life expectancy.
  3. How is pleural mesothelioma diagnosed?Pleural mesothelioma is diagnosed using a combination of imaging tests (such as X-rays, CT scans, and MRIs), blood tests, and biopsies.
  4. What is the difference between pleural mesothelioma and other types of mesothelioma?Pleural mesothelioma affects the lining of the lungs (the pleura), while other types of mesothelioma affect different parts of the body. Peritoneal mesothelioma affects the lining of the abdominal cavity (the peritoneum), and pericardial mesothelioma affects the lining of the heart (the pericardium). Each type of mesothelioma has its own set of symptoms, challenges, and treatment options.